Hacker News
- Scientists Find Brain Hormone That Triggers Fat Burning http://www.scripps.edu/news/press/2017/20170127srinivasan.html 16 comments
- New drug has potential to turn COVID-19 virus against itself: Scripps Research team showed that a variation of an already FDA-approved therapeutic for neurological disease can block COVID-19 infection in animals https://www.scripps.edu/news-and-events/press-room/2022/20220929-lipton-covid.html 16 comments science
- Four billion years ago, Earth looked very different, devoid of life, covered by ocean. Scientists discovered a new set of chemical reactions that use cyanide, ammonia, carbon dioxide, all thought to be common, to generate amino acids and nucleic acids, the building blocks of proteins and DNA. https://www.scripps.edu/news-and-events/press-room/2022/20220728-krishnamurthy-origins-of-life-chemical-reactions.html 21 comments science
- “Scientists at Scripps Research have invented a way to image, across different tissues and with higher precision than ever before, where drugs bind to their targets in the body. The new method could become a routine tool in drug development” https://www.scripps.edu/news-and-events/press-room/2022/20220427-ye-catch.html 3 comments science
- Compound in the herb rosemary may be useful against COVID-19 and other inflammatory diseases. Carnosic acid, a compound found in the herb rosemary, can block SARS-CoV-2 infection and reduce inflammation.The compound appears to have previously been associated with a reduction in Alzheimer’s symptoms. https://www.scripps.edu/news-and-events/press-room/2022/20220201-lipton-rosemary-covid19.html 40 comments science
- A group of medications long prescribed to treat tapeworm has inspired a compound that shows two-pronged effectiveness against COVID-19. The compound—part of a class of molecules called salicylanilides—blocks viral material from getting out of the endosome, and it just gets degraded. https://www.scripps.edu/news-and-events/press-room/2021/20210806-janda-potential-covid19-drug-tapeworm-medications.html 36 comments science
- First-in-human clinical trial confirms novel HIV vaccine approach developed by IAVI and Scripps Research https://www.scripps.edu/news-and-events/press-room/2021/20210203-hiv-vaccine.html 61 comments science
- Scientists reprogram immune B cells using CRISPR to produce same broadly neutralizing HIV antibodies found in rare HIV patients. These engineered immune cells elicit broad response to HIV in mice, offering hope for vaccine or functional cure against numerous strains of the fast-evolving virus. https://www.scripps.edu/news-and-events/press-room/2020/20201118-voss-hiv.html 37 comments science
- A tiny genetic mutation that increases functional spikes 4-5 times in the SARS-coV-2 variant circulating throughout Europe and the United States, significantly increases the virus’ ability to infect cells, lab experiments show. https://www.scripps.edu/news-and-events/press-room/2020/20200611-choe-farzan-sars-cov-2-spike-protein.html 3 comments science
- Mutated coronavirus spreading in U.S. shows significant boost in infectivity in lab experiments https://www.scripps.edu/news-and-events/press-room/2020/20200612-choe-farzan-coronavirus-spike-mutation.html 16 comments science
- New research shows how general anesthesia induces unconsciousness. A "billiard-like break shot" scatters lipid clusters in cell membranes, which releases an enzyme that liberates potassium from ion channels, leaving neurons hyper-polarized and inhibiting their ability to fire. https://www.scripps.edu/news-and-events/press-room/2020/20200529-hansen-lerner-anesthesia.html 1129 comments science
- Prescription drug costs steadily soar, yet price transparency is lacking: A new study found ‘continual, marked, annual increases’ of the country’s 49 most popular brand-name drugs. “It is especially concerning to see drugs in the same class having increases that appear to be coordinated.” https://www.scripps.edu/news-and-events/press-room/2019/20190531-topolwineinger-drugprices.html 123 comments science
- Fitness wearables may improve real-time tracking of seasonal influenza outbreaks https://www.scripps.edu/news-and-events/press-room/2020/20200116-wearable-flu.html 3 comments privacy
- The COVID-19 coronavirus epidemic has a natural origin, scientists say https://www.scripps.edu/news-and-events/press-room/2020/20200317-andersen-covid-19-coronavirus.html 141 comments worldnews
- Discovery of ‘hidden’ outbreak in Cuba hints that Zika virus can spread silently https://www.scripps.edu/news-and-events/press-room/2019/20190822-andersen-zika.html 27 comments science
- Prescription drug costs steadily soar, yet price transparency is lacking: A new US study found continual, marked, annual increases of 49 most popular brand-name drugs, with drugs in the same class having increases that appear to be coordinated, with price jumps often timed with competitors. https://www.scripps.edu/news-and-events/press-room/2019/20190531-topolwineinger-drugprices.html 4 comments science
- Since the ice bucket challenge went viral in 2014, scientists have discovered a new RNA-binding compound that blocks the most common genetic cause of both familial ALS and frontotemporal dementia. Scientists are assessing its potential to become a drug to treat both these diseases. https://www.scripps.edu/news-and-events/press-room/2018/20181217-disney-als.html 190 comments science
- HIV vaccine protects non-human primates from infection: The new study shows that rhesus macaque monkeys can be prompted to produce neutralizing antibodies against one strain of HIV that resembles the resilient viral form that most commonly infects people, called a Tier 2 virus. https://www.scripps.edu/news-and-events/press-room/2018/20181214-burton-hiv.html 8 comments science
- Scientists at Scripps Research show for the first time exactly how human antibodies can bind to the Ebola virus and stop infection, not only for Ebola virus, but capable of neutralizing closely related infections from all members of the Ebolavirus genus. https://www.scripps.edu/news-and-events/press-room/2018/20180912-ebola-antibody-therapy.html 3 comments science
- Scientists have discovered a new target for treating major depressive disorder, a disease that affects more than 16 million American adults. Their research shows that individuals with high levels of an enigmatic receptor called GPR158 may be more susceptible to depression following chronic stress. https://www.scripps.edu/news/press/2018/stress_depression.html 3 comments science
- Chemists discover plausible recipe for early life on Earth. http://www.scripps.edu/news/press/2018/20180108krishnamurthy.html 6 comments science
- Scientists Find Potential “Missing Link” in Chemistry That Led to Life on Earth http://www.scripps.edu/news/press/2017/20171106krishnamurthy.html 114 comments science
- Anti-Heroin Vaccine Found Effective in Non-Human Primates for up to Eight Months After Administration https://www.scripps.edu/newsandviews/e_20170703/janda_nv_20170703.html 98 comments science
- Anti-heroin vaccine found effective in rhesus monkeys http://www.scripps.edu/news/press/2017/20170606janda.html 70 comments science
- Scientists create stable "semi-synthetic" organism that uses four natural DNA bases A, T, C and G + two synthetic bases called X and Y http://www.scripps.edu/news/press/2017/20170123romesberg.html 6 comments science
- Scientists Discover Antibodies that Target Holes in HIV's Defenses: New Findings Could Lead to New AIDS Vaccine Candidates http://www.scripps.edu/news/press/2016/20160912burtoncell.html 6 comments science
- Fundamental flaw in common lab technique: Gas chromatography mass spectrometry fundamentally alters the samples it analyses. http://www.scripps.edu/newsandviews/e_20151012/siuzdak.html 3 comments science
- Researchers develop possible therapy for preventing drug addiction and relapse by erasing all memories associated with drug use http://www.scripps.edu/news/press/2015/20150804miller.html 4 comments science
- Scripps Research, Mayo Clinic Scientists Find New Class of Drugs that Dramatically Increases Healthy Lifespan http://www.scripps.edu/news/press/2015/20150309agingcell.html 3 comments science
- Born Deaf But Hearing Restored with Insertion of Gene http://www.scripps.edu/newsandviews/e_20141208/mueller.html 6 comments science
- Chemists uncover powerful new click chemistry reactivity: The findings open a doorway on an unexplored chemical galaxy containing vast numbers of new molecules for making drugs, plastics and unprecedented smart materials http://www.scripps.edu/news/press/2014/20140813sharpless.html 85 comments science
- Researchers identify the protein activated by short intense bouts of exercise. Genetically alterd mice which expressed this protein had a 15 percent increase in muscle mass without exercising. http://www.scripps.edu/news/press/2014/20140605conkright.html 425 comments science
- The ultimate decoy - Protein that helps bacteria misdirect immune system: Scientists discovered an unusual bacterial protein that attaches to antibody and prevents it from binding to its target. This protein probably helps some bacteria evade the immune response and establish long-term infections http://www.scripps.edu/news/press/2014/20140206lerner.html 31 comments science
- New way to map important drug targets: Researchers have used new techniques and one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper in a more natural state than possible before. http://www.scripps.edu/news/press/2013/20131219cherezov.html 3 comments science
- For the first time scientists have been able to erase dangerous drug-associated memories in mice and rats without affecting other more benign memories. The surprising discovery points to a clear and workable method to disrupt unwanted memories while leaving the rest intact. http://www.scripps.edu/news/press/2013/20130910miller.html 9 comments science
- new drug offers promise of exercise in pill form - Drug Candidate Designed at Scripps Research Institute Leads to Improved Endurance http://www.scripps.edu/news/press/2013/20130714burris.html 10 comments science
- New drug (SR9009) mimics the beneficial effects of exercise http://www.scripps.edu/newsandviews/e_20130729/burris.html 40 comments science
- Scientists Identify First Potentially Effective Therapy for Human Prion Disease http://www.scripps.edu/news/press/2013/20130403lasmezas.html 11 comments science
- Scientists have unveiled a new technique for vaccine design that could be particularly useful against HIV and other fast-changing viruses http://www.scripps.edu/news/press/2013/20130328schief.html 34 comments science
- Scientists Uncover a Previously Unknown Mechanism of Memory Formation http://www.scripps.edu/news/press/2013/201301230miller.html 18 comments science