- Pig-to-Baboon Heart Transplant Survives Nearly Nine Months, researchers at the University of Maryland find. The pig heart was able to successfully handle the stress of pumping blood throughout the body and is an advancement on the path to transplanting pig hearts into humans. https://www.immunofrontiers.com/pig-to-baboon-heart-transplant-survives-nearly-nine-months 6 comments science
- Dual immune response to both cancer and SARS-CoV-2 stimulated by single dose of cell-based vaccine developed by a team of Japanese scientists. The new vaccine strategy could offer enhanced protection to immunocompromised cancer patients that may be underprotected by existing COVID-19 vaccines. https://www.immunofrontiers.com/cell-based-vaccine-confers-protection-to-both-sars-cov-2-and-cancer 2 comments science
- A German study has "important implications in terms of potential therapies for arthritis," a condition that affects 1 in 5 Americans. Fibroblasts, key mediators of the disease, were found undergo metabolic changes associated with the immune system and these changes could be targeted therapeutically. https://www.immunofrontiers.com/fibroblasts-and-complement-implicated-in-recurrent-arthritic-inflammation 3 comments science
- "Blue LEDs could be used as a nonpharmacological treatment for pancreatic cancer," South Korean scientists concluded based on their research published in the Journal of Cellular Physiology. This is the first study to show the potential of this form of light therapy for treating this deadly disease. https://www.immunofrontiers.com/led-irradiation-may-reduce-survival-and-growth-of-pancreatic-cancer 7 comments science
- Unexpectedly, Cholera Toxin has been used to enable the administration of IL-10, an anti-inflammatory drug that otherwise had limiting side effects. This novel fusion therapy avoids the toxicities of IL-10 and showed promise in animal studies for treating Ulcerative Colitis and Crohn's Disease. https://www.immunofrontiers.com/novel-colitis-and-crohns-treatment-uses-cholera-toxin-to-deliver-il-10 73 comments science
- Endurance exercise, such as jogging, has been shown to influence the immune system and could help to explain the known association between physical activity and human health, including chronic diseases such as cancer. https://www.immunofrontiers.com/endurance-exercise-found-to-influence-pd-1-expression-by-cd8-t-cells 28 comments worldnews
- Endurance exercise, such as jogging, has been shown to influence the expression of PD-1 by CD8+ T cells. The study, by German scientists, could help to explain the known association between physical activity and human health, including chronic diseases such as cancer that are affected by PD-1. https://www.immunofrontiers.com/endurance-exercise-found-to-influence-pd-1-expression-by-cd8-t-cells 3 comments science
- Regular application of moisturizers to the skin of young infants has been associated with the development of food allergies by scientists from the United Kingdom. Their findings provide new insight on this important public health problem. https://www.immunofrontiers.com/regular-moisturizer-use-on-infant-skin-associated-with-food-allergy-onset 283 comments science
- A new cancer therapy simultaneously zaps tumors with imaging-guided laser radiation and stimulates the anti-cancer immune response. This technology, developed by South Korean scientists, combines photodynamic therapy with immunotherapy for the treatment of cancer and is the first of its kind. https://www.immunofrontiers.com/exosome-based-imaging-guided-cancer-therapy-activates-immune-cells 192 comments science
- Virtual Reality is "feasible and acceptable" for managing "pain and distress" among children treated with intravenous procedures in the emergency room, Canadian researchers discovered. Children, their parents, and healthcare providers all reported high levels of satisfaction with VR's clinical use. https://www.immunofrontiers.com/virtual-reality-feasible-for-improving-comfort-of-pediatric-iv-procedures 18 comments science
- Scientists have shown that a non-invasive blood test can identify cancer up to four years prior to conventional diagnosis. The assay has a high degree of specificity for five common cancer types- liver, lung, colorectal, stomach, and esophageal- and could contribute to reducing disease mortality. https://www.immunofrontiers.com/non-invasive-blood-test-can-detect-cancer-years-prior-to-diagnosis 285 comments science
- German scientists have discovered the basis for an immunosuppression mechanism that is associated with poor cancer patient prognosis and resistance to treatment. Now, the anti-tumor immune response could be given a boost, and diagnostics/treatments for other inflammatory diseases could be developed. https://www.immunofrontiers.com/mdsc-metabolite-found-to-underly-immunosuppression-may-aid-cancer-therapy 3 comments science
- Portuguese researchers have discovered, unexpectedly, that the development of powerful cancer and disease-killing T cells within human tissues is promoted by cells with anti-inflammatory properties. The finding could support the creation of the next generation of vaccines and cancer immunotherapies. https://www.immunofrontiers.com/regulatory-t-cells-found-to-promote-the-development-of-cd8-trm-t-cells 86 comments science
- Researchers have built a genetic atlas of immune cells that cause toxic oxidative stress in the brain, discovering a compound with "potent therapeutic effects" in an animal model of Multiple Sclerosis. Their work may lead to better therapies for Parkinson's, MS, and other neurodegenerative diseases. https://www.immunofrontiers.com/researchers-profile-immune-cells-implicated-in-neurodegenerative-diseases 3 comments science
- A study evaluating the aging immune system has discovered that the function of human T cells, a cell population critical for protection against disease, is altered over time by a family of stress-sensing proteins known as sestrins. Now, the efficacy of vaccines could be boosted in older adults. https://www.immunofrontiers.com/altered-function-of-aging-cd8-t-cells-linked-to-stress-sensing-sestrins 11 comments science
- A drug that is FDA-approved for treating alcohol addiction has been found, unexpectedly, to also reduce the inflammation associated with a variety of life-threatening conditions including sepsis and COVID-19. Now, the drug could be a "powerful therapeutic" for diseases from Alzheimer's to diabetes. https://www.immunofrontiers.com/addiction-treating-drug-also-prevents-inflammation-researchers-find 74 comments science
- An immunotherapy for metastatic pancreatic cancer has led to an "ongoing, durable, complete response" in a human patient 6 months after treatment. The therapy, based on a type of white blood cell called natural killer cells, was successful in a phase 1 clinical trial and is entering phase 2 trials. https://www.immunofrontiers.com/nantkwest-plans-phase-2-trial-of-nk-cell-pancreatic-cancer-immunotherapy 53 comments science
- An immunotherapy for metastatic pancreatic cancer has led to an "ongoing, durable, complete response" in a human patient 6 months after treatment. The therapy, based on a type of white blood cell called natural killer cells, was successful in a phase 1 clinical trial and is entering phase 2 trials. https://www.immunofrontiers.com/nantkwest-plans-phase-2-trial-of-nk-cell-pancreatic-cancer-immunotherapy 11 comments science