- Microglial sex affects Alzheimer’s disease https://stm.sciencemag.org/content/12/525/eaba2905 9 comments science
- Low doses of 'laughing gas' could be fast, effective treatment for severe depression https://stm.sciencemag.org/content/13/597/eabe1376 929 comments science
- New study explores why many patients with COVID-19 lose their sense of smell or taste, showing the SARS-CoV-2 virus can persist & promote inflammation in the olfactory system in patients & brain infections in hamsters. https://stm.sciencemag.org/content/early/2021/04/30/scitranslmed.abf8396?utm_campaign=scimag&utm_source=jhubbard&utm_medium=twitter 4 comments science
- Antidepressant drug Paroxetine found to be a disease-modifying treatment for Osteoarthritis https://stm.sciencemag.org/content/13/580/eaau8491 31 comments science
- COVID-19 Linked to Blood Clotting https://stm.sciencemag.org/content/early/2020/11/02/scitranslmed.abd3876 6 comments science
- Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study https://stm.sciencemag.org/content/12/564/eabb2830 10 comments science
- According to a new study, a nanoparticle RNA vaccine for the COVID-19 virus safely elicited the production of antibodies and T cell responses—with antibodies lasting more than 70 days—completely neutralizing the coronavirus. https://stm.sciencemag.org/content/early/2020/07/20/scitranslmed.abc9396.full 54 comments science
- An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice https://stm.sciencemag.org/content/early/2020/04/03/scitranslmed.abb5883 15 comments science
- A new oral contraceptive that only has to be taken once a month, could reduce unintended pregnancies that result from forgetting to take a daily dose. This kind of monthly contraceptive could have a significant impact on the health of women and their families, especially in the developing world. https://stm.sciencemag.org/content/11/521/eaay2602 122 comments science
- Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation - Lijuan Xing1, Guangsen Shi, Yulia Mostovoy, Nicholas W. Gentry, Zenghua Fa1, Thomas B. McMahon, Pui-Yan Kwok, Christopher R. Jones, Louis J. Ptáček,† and Ying-Hui Fu. https://stm.sciencemag.org/content/11/514/eaax2014 3 comments science
- The gut microbiota influences skeletal muscle mass and function in mice (July 2019) Transplanting the gut microbiota from pathogen-free mice into germ-free mice resulted in an increase in skeletal muscle mass, a reduction in muscle atrophy markers, improved oxidative metabolic capacity, and more.. https://stm.sciencemag.org/content/11/502/eaan5662 4 comments science
- Researchers develop an antibody that bridges T-cells to ovarian cancer cells, allowing the immune cell to eradicate ovarian tumors in preclinical models; currently being tested in Phase 1 trials. May have applications in other tumor types, such as pancreatic cancer, as well. https://stm.sciencemag.org/content/11/497/eaau7534 10 comments science
- The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans https://stm.sciencemag.org/content/11/489/eaav0120 3 comments science
- Detecting cancer in plasma with cell-free DNA and their genome fragmentation signature. Towards tests for detecting challenging cancers for "liquid biopsy" (brain, renal cancer). http://stm.sciencemag.org/content/10/466/eaat4921 3 comments science
- Safe and effective ALS (Lou Gehrig's disease) treatment possible using artificial microRNA in macaques - University of Massachusetts http://stm.sciencemag.org/content/10/465/eaau6414 7 comments science
- Researchers have been on the hunt for new drugs to combat bacterial 'superbugs.' A new report describes success using gallium, a metal that bacteria confuse for iron, which they take up as a nutrient. Gallium, however, works as a Trojan horse, disrupting bacteria's ability to multiply. http://stm.sciencemag.org/content/10/460/eaat7520 5 comments science
- Germs gaining resistance to hand gels in hospitals: Increasing tolerance of hospital Enterococcus faecium to handwash alcohols http://stm.sciencemag.org/content/10/452/eaar6115 23 comments science
- What does research reproducibility mean. http://stm.sciencemag.org/content/8/341/341ps12.full 3 comments science
- A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice[Triclosan increased the severity of colitis symptoms and spurred colitis-associated colon cancer cell growth] http://stm.sciencemag.org/content/10/443/eaan4116 3 comments science
- Mumps virus outbreaks in Europe and the U.S. are linked to waning effectiveness of the vaccine: the increase in cases are more consistent with the loss of efficacy over time, rather than incomplete protection against an evolving virus. An additional dose, however, may extend protection. http://stm.sciencemag.org/content/10/433/eaao5945 7 comments science
- Scientists successfully reduce tinnitus (constant ringing in ears) in human subjects http://stm.sciencemag.org/content/10/422/eaal3175/tab-pdf 96 comments science
- Auditory stimulation with an experimental device using precisely timed sounds and weak electrical pulses reduced tinnitus in humans in a double-blinded, sham-controlled, crossover clinical study. http://stm.sciencemag.org/content/10/422/eaal3175.full 3 comments science
- A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders http://stm.sciencemag.org/content/9/401/eaam9171 24 comments science
- Researchers created engineered liver tissue that expands after transplant. http://stm.sciencemag.org/content/9/399/eaah5505 4 comments science
- A vitamin to D-crease sunburn | Science Translational Medicine http://stm.sciencemag.org/content/9/394/eaan5233 3 comments science
- Soft robotic silicone sleeve ribbed with inflatable tubes wraps around a waning heart and provides extra muscle power to pump blood and supports heart function http://stm.sciencemag.org/content/9/373/eaaf3925 3 comments science
- Researchers tested a genetically attenuated malaria parasite as a vaccine in 10 human volunteers using infected mosquito bites with a single exposure consisting of 150 to 200 bites per subject. All subjects remained blood stage–negative and developed inhibitory antibodies to malaria parasites. http://stm.sciencemag.org/content/9/371/eaad9099 16 comments science
- Early changes in CSF sTREM2 in dominantly inherited Alzheimer’s disease occur after amyloid deposition and neuronal injury http://stm.sciencemag.org/content/8/369/369ra178 10 comments science
- An Alzheimer’s drug, verubecestat, has been shown to effectively “switched off” the production of toxic amyloid proteins that lead to the sticky plaques seen in the brains of Alzheimer’s patients by halting the steady production of amyloid-beta proteins through blocking a brain enzyme called BACE1. http://stm.sciencemag.org/content/8/363/363ra150.full 8 comments science
- DNA in saliva reveals the presence of head and neck cancer. http://stm.sciencemag.org/content/7/293/293ra104 23 comments science
- New ultrasound-based Alzheimer’s treatment restores memory function http://stm.sciencemag.org/content/7/278/278ra33 6 comments science
- Breakthrough discovery in cancer treatment: Immunological mechanisms of the antitumor effects of supplemental oxygenation http://stm.sciencemag.org/content/7/277/277ra30 5 comments science
- Breakthrough discovery in cancer treatment http://stm.sciencemag.org/content/7/277/277ra30 3 comments science
- Drug can return adult brain, to "child-like" learning state http://stm.sciencemag.org/content/6/258/258ra140.full 817 comments science
- Scientists have discovered how to inject substances into the human brain, offering potential to treat Alzheimer’s. The research proposes that those suffering from the disease could be given a weekly injection and, in effect, be cured. http://stm.sciencemag.org/content/6/261/261ra154 182 comments science
- Antibiotics affect mitochondria the same way as bacteria. Hope for antibiotic resistance in humans http://stm.sciencemag.org/content/5/192/192ra85.short 5 comments science
- Oxytocin (hugs and kisses) decreases reward-based food consumption (junk food cravings) in humans. Bonding with people can help you lose weight. http://stm.sciencemag.org/content/5/208/208ec173.short 94 comments science
- Chemical in red wine kills cancer cells even after it's metabolized http://stm.sciencemag.org/content/5/205/205ra133.abstract 75 comments science
- Science Translational Medicine publishes a paper that shows the DNA (plasmid-based) immunotherapies create potent immune responses in people - including Cytotoxic T Lymphocytes http://stm.sciencemag.org/content/4/155/155ra138 8 comments science
- Scientists discover previously unknown cleansing system in brain http://stm.sciencemag.org/content/4/147/147ra111 12 comments cogsci