- AAGR: A ketogenic diet has a strong anti-tumor effect in multiple pancreatic cancer mouse models, and the effect is likely a result of the low glucose and increased fatty acid load associated with the diet. https://aacrjournals.org/cancerres/article/84/2_Supplement/B050/732916#:~:text=A%20ketogenic%20diet%20has,antioxidant%20and%20mitochondrial%20inhibitors. 2 comments science
- Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells (Nov 2023) https://aacrjournals.org/cancerres/article/83/21/3529/729716/Fasting-Mimicking-Diet-Drives-Antitumor-Immunity 15 comments science
- A dendritic cell vaccine administered before and after autologous stem cell transplant was safe and associated with durable clinical responses in patients with high-risk multiple myeloma. After 4.2 years, 6 out of 7 patients who had a positive clinical response were alive and remained disease-free. https://aacrjournals.org/clincancerres/article-abstract/doi/10.1158/1078-0432.CCR-22-3987/729137/Survivin-Dendritic-Cell-Vaccine-Safely-Induces?redirectedFrom=fulltext 3 comments science
- Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade | Cancer Discovery (Sept 2023) https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-22-1301/729147/Formate-supplementation-enhances-anti-tumor-CD8-T?redirectedFrom=fulltext 3 comments science
- Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy (Sept 2023) https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-23-0464/729224/Fructose-induced-mTORC1-Activation-Promotes 5 comments science
- Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia (2023) https://aacrjournals.org/cancerrescommun/article/3/2/297/716657/Combination-of-a-New-Oral-Demethylating-Agent 3 comments science
- Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice — effect of a KG was significant in female KPC mice (60% increase in median overall survival) https://aacrjournals.org/cancerrescommun/article/2/9/951/709078/A-Ketogenic-Diet-in-Combination-with-Gemcitabine 4 comments science
- Mitochondrial uncoupling induces epigenome remodeling and promotes differentiation in neuroblastoma, providing an approach to reverse the Warburg effect and suppress tumor growth. https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-22-1029/710152/Mitochondrial-uncoupling-induces-epigenome 6 comments science
- Aerobic exercise can reduce the risk of metastatic cancer by 72%. According to the researchers, intensity aerobic exercise increases the glucose (sugar) consumption of internal organs, thereby reducing the availability of energy to the tumor. https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-22-0237/709159/An-exercise-induced-metabolic-shield-in-distant 79 comments science
- Two top cancer organizations highlight how e-cigarettes are linked with early steps in cancer development and call for flavor bans https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-22-2429/709888/Electronic-Nicotine-Delivery-Systems-An-Updated 326 comments science
- Drinking too many sugary beverages may increase the risk of death from cancer, study finds https://aacrjournals.org/cebp/article-abstract/doi/10.1158/1055-9965.EPI-22-0392/709016/Sugar-and-Artificially-Sweetened-Beverages-and?redirectedFrom=fulltext 24 comments science
- Johns Hopkins Doctors Discover That a Common Infection May Cause Cancer. A new study suggests that Clostridioides difficile is responsible for certain colorectal cancers. https://aacrjournals.org/cancerdiscovery/article-abstract/12/8/1886/707235/Sequential-Single-Cell-Transcriptional-and-Protein 11 comments health
- Johns Hopkins Doctors Discover That a Common Infection May Cause Cancer. A new study suggests that Clostridioides difficile is responsible for certain colorectal cancers. https://aacrjournals.org/cancerdiscovery/article-abstract/12/8/1886/707235/Sequential-Single-Cell-Transcriptional-and-Protein 2 comments science
- Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer | Cancer Discovery https://aacrjournals.org/cancerdiscovery/article-abstract/12/6/1462/699170/Reverse-Transcriptase-Inhibition-Disrupts-Repeat?redirectedFrom=fulltext 2 comments science
- Prostate cancer hijacks tumor cell biorhythm to evade hormone therapy: Hormone therapy is successful at keeping metastatic prostate cancer under control, but eventually the tumor cells become resistant to it. https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-21-0576/704952/Drug-induced-epigenomic-plasticity-reprograms 2 comments science