- A potent and selective nociceptin receptor antagonist, BTRX-246040, shows anti depressant effect in rodent models, further challenging the idea of the monoamine hypothesis of depression. It is currently in Phase II for MDD. https://www.mdpi.com/1420-3049/27/2/533 7 comments science
Linked pages
- Antidepressant-Like Actions of Inhibitors of Poly(ADP-Ribose) Polymerase in Rodent Models | International Journal of Neuropsychopharmacology | Oxford Academic https://academic.oup.com/ijnp/advance-article/doi/10.1093/ijnp/pyab077/6427794 96 comments
- Creative Commons — Attribution 4.0 International — CC BY 4.0 https://creativecommons.org/licenses/by/4.0/ 95 comments
- Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome | Nucleic Acids Research | Oxford Academic https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac847/6749541 83 comments
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