- The Y chromosome can be lost through the process of aging, & this can lead to an increased risk of heart failure & cardiovascular disease. Men die on average several years younger than women, a difference that previous studies have linked to loss of the Y chromosome in the white blood cells of men. https://theconversation.com/y-chromosome-loss-through-aging-can-lead-to-an-increased-risk-of-heart-failure-and-death-from-cardiovascular-disease-new-research-finds-186797 377 comments science