- Role of serotonin, estrogen, and TNF-α in the paroxetine-impaired steroidogenesis and testicular macrophages polarization. Conclusion: (...) The unrecovered testicular changes after treatment discontinuation are due to persistent paroxetine serotonin/estrogen effects. https://onlinelibrary.wiley.com/doi/abs/10.1111/andr.13513 7 comments science