Hacker News
- Science Discussion Series: Solanezumab – a monoclonal antibody intended to treat Alzheimer’s disease - fails to meet primary endpoint in Phase III trial. Implications for AD therapy and the amyloid hypothesis. https://www.reddit.com/r/science/comments/5hdt4t/science_discussion_series_solanezumab_a/ 8 comments science
- “Amyloid hypothesis” guides research on Alzheimer’s, but failed trials raised questions about the theory. Breakdowns in the brain's axonal transport system can lead to “traffic jams,” and a new study hypothesizes that they precede the formation of plaques in neurological diseases like Alzheimer’s. https://www.buffalo.edu/news/releases/2018/06/003.html 3 comments science
- Alzheimer’s drug fails in large clinical trial, casting doubt on amyloid hypothesis: "We may very well be nearing the end of the amyloid hypothesis rope, at which point one or two more failures will cause us to loosen our grip and let go". https://www.statnews.com/2018/01/24/lilly-latest-alzheimers-drug-fail/ 135 comments science