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- CRISPR gene-editing breakthrough opens door to treating broad array of diseases https://www.npr.org/sections/health-shots/2021/06/26/1009817539/he-inherited-a-devastating-disease-a-crispr-gene-editing-breakthrough-stopped-it 234 comments
- The gene-editing technology CRISPR–Cas has been used for the first time in human embryos grown in vitro to correct a disease-associated mutation https://www.nature.com/nature/journal/vaop/ncurrent/full/nature23533.html 3 comments science
- Gene-editing using CRISPR have the potential to permanently modify disease-causing genes. Scientists demonstrate that CRISPR base editors delivered using lipid nanoparticles can modify disease-related genes in living monkeys to lower cholesterol by ~60% after a single-dose treatment. https://www.nature.com/articles/s41586-021-03534-y?t=au 101 comments science
- He Inherited A Devastating Disease. A CRISPR Gene-Editing Breakthrough Stopped It https://www.npr.org/sections/health-shots/2021/06/26/1009817539/he-inherited-a-devastating-disease-a-crispr-gene-editing-breakthrough-stopped-it 22 comments technology
- Researchers have rendered a population of mosquitoes in a lab sterile using the gene-editing tool CRISPR-Cas9 by homing in on a specific target in insect DNA -- the doublesex gene -- raising the possibility of eradicating disease-carrying species of the insect entirely https://www.nature.com/articles/nbt.4245 7 comments science
- The parasites that cause leishmaniasis, a disfiguring skin disease affecting about 12 million people globally, may have met their match in vaccines developed using CRISPR gene-editing technology, new research suggests. https://news.osu.edu/vaccine-protects-against-tough-cookie-parasite-found-in-the-americas/ 89 comments science
- Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that causes leishmaniasis, a skin disease common in tropical regions of the world and gaining ground in the United States. https://news.osu.edu/something-old-something-new-combine-for-effective-vaccine-against-parasitic-skin-disease/ 13 comments science
- First ever gene-edited ticks using CRISPR offer new weapons against Lyme disease https://newatlas.com/science/first-gene-edited-ticks-weapons-lyme-disease/ 181 comments science
- CRISPR gene-editing has been tested in a human for the first time - "Chinese scientists have become the first in the world to inject an adult human with cells that have been genetically edited" - "The new gene-editing technique is poised to revolutionise the way we treat disease" http://www.sciencealert.com/crispr-gene-editing-has-been-tested-in-a-human-for-the-first-time 5 comments worldnews
- Landmark CRISPR trial shows promise against deadly disease. The study is the first to suggest that administering a gene-editing treatment directly into the body could be a safe and effective treatment. https://www.nature.com/articles/d41586-021-01776-4?amp%3Butm_campaign=nature&%3Butm_medium=social 6 comments science
- Scientists used gene-editing technology to cure 100% of cancer-infected mice and achieved complete cure in animal experiments. The team used a genetic engineering technique called CRISPR that cuts the DNA strand and locks the diseased genes. This project will complete an experiment on a human soon. http://healthichs.com/scientists-use-gene-editing-technology-to-cure-100-of-cancer-infected-mice/ 3 comments science
- Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells http://www.nature.com/cr/journal/v25/n1/full/cr2014160a.html 6 comments science
- Chinese Scientists Will Use CRISPR Gene Editing on Humans for the First Time: If successful, it could pave the way for more CRISPR-based treatments, potentially revolutionizing the way we treat a wide variety of diseases and ailments. http://www.popularmechanics.com/science/health/a22009/chinese-scientists-will-use-crispr-gene-editing-on-humans/ 3 comments technology
- Crispr Gene Editing Is Coming for the Womb: In utero gene editing for monogenic lung disease [proof-of-concept in mice] https://www.wired.com/story/crispr-gene-editing-is-coming-for-the-womb/ 5 comments science
- AskScience AMA Series: I'm Alex Marson and I'm an immunologist at UCSF. My lab is building more efficient CRISPR-based gene editing tools to supercharge the human immune system to fight cancer, infectious disease, and autoimmunity. AMA! https://www.youtube.com/watch?v=iXgU--ugLqY 360 comments askscience
- CRISPR gene editing can treat heart disease and repair damaged tissue after a heart attack https://geneticliteracyproject.org/2023/02/03/crispr-gene-editing-can-treat-heart-disease-and-repair-damaged-tissue-after-a-heart-attack/ 365 comments futurology
- A CRISPR edit for heart disease:A one-off injection to reduce the risk of cardiovascular disease is now a prospect thanks to advances in gene editing. https://www.nature.com/articles/d41586-018-02482-4 278 comments science
- For the first time, scientists have performed prenatal gene editing using both CRISPR-Cas9 and base editor 3 (BE3) to prevent a lethal metabolic disorder in mice, offering the potential to treat human congenital diseases before birth, as reported today in Nature Medicine. https://www.pennmedicine.org/news/news-releases/2018/october/crispr-prenatal-gene-editing-shows-proof-of-concept-in-treating-congenital-disease-before-birth 32 comments science
- CRISPR-Cas9 gene editing successful for a patient with Sickle Cell Disease and another patient with transfusion dependent β-Thalassemia - More than a year later, both patients had clinically improved and no longer needed blood transfusions. (NEJM, 5 Dec 2020) https://www.nejm.org/doi/full/10.1056/nejmoa2031054 461 comments science
- Researchers use gene editing with CRISPR to treat lethal lung diseases before birth in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study shows that in utero editing could be a promising new approach for treating lung diseases before birth. https://www.chop.edu/news/researchers-use-gene-editing-crispr-treat-lethal-lung-diseases-birth 41 comments science
- A potential cure for sickle cell disease: Researchers used CRISPR-Cas9 to edit genes in stem cells taken from 3 sickle cell disease patients to increase production of fetal hemoglobin (HbF). They then received their own edited cells as infusions. All 3 had reduced symptoms and clinical improvements. https://www.nejm.org/doi/10.1056/NEJMoa2215643 8 comments science
- Scientists say they have used the gene editing tool Crispr-Cas9 inside a person’s body for the first time, a new development in efforts to operate on DNA to treat diseases. https://www.theguardian.com/science/2020/mar/04/doctors-use-gene-editing-tool-crispr-inside-body-for-first-time 16 comments worldnews
- Discovery of a “hidden gem” enables gene editing with a small but mighty CRISPR-Cas3 system - Enhanced research tool is a potential boon for research in genetic diseases and developmental biology https://www.eurekalert.org/news-releases/940614 2 comments science
- A Decade After CRISPR Discovery, the Unimaginable Outcomes of Gene Editing Emerge. CRISPR-based cures will soon help combat all kinds of disease, from UTIs to leukemia. But terrifying implications of gene editing abound as well. https://archive.fo/tPBIG 50 comments futurology
- Scientists develop CRISPR-SKIP, a new CRISPR technique that skips over portions of genes that can cause disease, instead of turning them off by breaking the DNA. Such targeted editing could one day treat genetic diseases such as Duchenne’s muscular dystrophy, Huntington’s disease or some cancers. https://news.illinois.edu/view/6367/683492 54 comments science
- Scientists have developed a CRISPR-Cas13 gene editing therapy against the RNA virus that causes hand, foot, and mouth disease, eliminating the virus in mouse models. The EV-A71 virus in severe cases can lead to nervous system disease and death. https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(23)00247-5/fulltext 43 comments science